A new paradigm for treating autoimmune disease

Our unique approach specifically and selectively reprograms immune cells that are activated in autoimmune disease, altering their metabolism to restore natural control.

By reprogramming immune cell metabolism, we can break the cycle of inflammation, restoring balance and allowing repair functions to resume.

Lisa Patel Lisa Patel Chief Scientific Officer

Drugs that harness immunometabolism

Istesso is pioneering new ways to reprogram the metabolism of specific immune cells to reduce inflammation and simultaneously support repair.

Altering the behaviour of mitochondria triggers changes inside immune cells that entirely alter their fate and function, dampening inflammation and reducing the signs and symptoms of disease.

Martyn Foster Biology and Experimental Pathology

All cells undergo a complex sequence of chemical reactions which produce or consume energy to maintain life. Collectively called metabolism, these reactions govern every aspect of biology.

In immune cells, metabolism regulates both cellular function and fate. When this gets out of balance, it can cause a wide variety of autoimmune diseases such as rheumatoid arthritis and multiple sclerosis, as well as certain types of cancer.

Our approach works without suppressing immune controls, meaning we can treat disease while maintaining normal immune function.

Immunometabolism & Istesso

The immune system is perhaps the most complex system in the human body other than the brain.

However, new insights have recently emerged into how the function of immune cells can be modulated by subtly altering their metabolism.

Immune cells are diverse and flexible. They can use a variety of chemical sequences to release energy by processing sugar, fat and protein. These metabolic pathways, along with a process called oxidative phosphorylation that occurs in cell structures called mitochondria, determine the cell’s function.

By influencing a cell to favour one metabolic pathway over another, we can profoundly change the cell’s behaviour. This leads to a potentially life-changing anti-inflammatory and repair effect in the case of autoimmune disease.

Reprogramming cells, treating disease

Istesso has a pipeline of novel compounds that reprogram cell metabolism. Under the action of these compounds, the cells choose alternative metabolic pathways, and their behaviour is selectively altered. Wayward cells implicated in autoimmune disease can be calmed, and the body rebalanced.

Before Treatment: In autoimmune disease, the immune cells are overactive, and attack the structural cells in the body’s nerves, skin, organs or joints. The cells’ ability to carry out repairs and normal functions is overwhelmed

Before Treatment

In autoimmune disease, the immune cells are overactive, and attack the structural cells in the body’s nerves, skin, organs or joints. The cells’ ability to carry out repairs and normal functions is overwhelmed.

Istesso’s research has revealed that the problem lies with the immune cells’ metabolism – the pathway through which they produce energy.

After Treatment: Istesso’s revolutionary approach reprograms the immune cells, altering their fate and function to normalise the immune response. This not only alleviates the symptoms of disease but allows the body to repair itself, restoring balance in the patient

After Treatment

Istesso’s revolutionary approach reprograms the immune cells, altering their fate and function to normalise the immune response. This not only alleviates the symptoms of disease but allows the body to repair itself, restoring balance in the patient.

The drug causes the immune cells to select an alternative metabolic pathway and stop producing cytokines that promote inflammation. The cells return to normal functions – an outcome impossible with current immunosuppressant drugs.

We’re asking really interesting, big questions about the control of inflammation and repair and getting really interesting, big answers with consequences for many chronic conditions.

Sam Williams Sam Williams Executive Chairman