Pipeline
Our investigational repair medicines work differently…
While conventional disease-modifying medicines can slow pathologic, symptomatic and functional decline, they cannot reverse disease and may suppress repair. Modulating the mitochondria – the beating heart of the body’s cells, responsible for energy production and central to everyday cell function – our compounds turn different metabolic pathways on or off. This changes how cells behave and function to promote the body’s natural ability to repair.
Our investigational treatments, all focussed on repair, target the underlying damage associated with chronic disease rather than the symptoms. This offers the potential to go beyond conventional disease modification by rebuilding damaged tissue in multiple settings of autoimmunity and fibrosis.
Leramistat is an investigational first-in-class, once-daily pill that works in an exciting new way, with strong promising results in bone and joint damage repair and protection without suppressing the immune system. A notable departure from current RA treatment approaches, leramistat works by augmenting the body’s inherent repair response to repair and restore damaged tissue as well as build resilience to cycles of further destruction. Our research suggests that the striking tissue repair benefits of leramistat could positively impact multiple chronic conditions of autoimmunity, fibrosis and bone loss.
Leramistat’s unique mode of action also supports adaptive repair in scarred lung tissue caused by idiopathic pulmonary fibrosis (IPF).
Leramistat has been granted both FDA Fast Track and Orphan Drug Designation (ODD) to support its development and expedite its review to fulfil an unmet medical need in IPF. You can access our expanded access policy here.
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