Restore Harmony. Extend Healthspan.

Istesso is rethinking how we extend healthspan as we age. Rather than trying to stop or slow disease progression, we focus on restoring the body’s natural capacity to repair itself and return to health.

Our pioneering approach centers on mitochondrial Complex I modulators, or MCMs, a new class of oral small molecule drugs that repair and regenerate tissue across multiple organs and disease settings. Our lead clinical program, leramistat, is in Phase 2 trials, and we are expanding MCMs to other chronic diseases of aging with a pipeline of assets, each holding blockbuster potential.